Research on Treatment of Diabetic Nephropathy

Objective: To observe the effects of combined telmisartan with alprostadil in treating diabetic nephropathy.Method:79 patients with type 2 diabetes complicating with diabetic nephropathy were randomly divided into group A(25 cases,alprostadil group),group B(27 cases,telmisartan),and group C(27 cases,combined medication).After 4-week treatment,the 24 hour urinary albumin excretion(24h UAE),blood urea nitrogen(BUN),serum creatinine(Scr),urine creatinine(Ucr),fasting blood glucose(FBG),MAP were detected and compared among the three groups.And,drug adverse reactions were observed.Result:After 4-week treatment,24h urine protein excretion and MAP all were obviously reduced among the three groups compared with before treatment(P0.05);Another combination therapy was more effective than alprostadil group and telmisartan group,the results were statistically significant.Conclusion:Combined telmisartan with alprostadil in treating diabetic nephropathy is an effective method.