EXPRESSION OF MULTIDRUG RESISTANCE GENE IN PRIMARY AND THE RELAPSED STATE ACUETE LEUKEMIAS

Objective:To investigate whether multidrug resistance(mdrl)gene was associated with the failure of chemotherapy in acute leukemia. Methods:With human mdrl probe,the mdrl gene expresSion level of 30 cases of acute leukemia was analvzed by non-radioactive in situ hybridization(NISH). Result:The mdrl gene expression levels were higher in acute leukemia patients with no response to the chemotherapy and in relapsed state than in patients before treatment and in patients with complete re-mission after treatment(P0.001,P0.01,respectively).Conclusion:These data suggest that ele-vated expression levels of mdrl mRNA levels might be one of the causes of no response to chemothera-py. Overexpression of mdrl gene suggests poor responses in primary and relapsed acute leukemias.