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2010•Chinese Journal of Health Laboratory TechnologyRequires access

Rapid detection of microcystin-LR in drinking water by ultra-fast liquid chromatography tandem mass spectrometry

Guilan Xu

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Abstract

Objective:To establish a rapid,accurate method detection microcystin-LR in drinking water.Methods:Using the m/z 498.4/135.0 for ions to establish the MRM method.After the water boil 30 minutes,using C18 solid phase extraction column to extract and purify then using 5 ml 0.1% formic acid methanol solution to elute,dried by nitrogen then constant volume to 1ml,pass the 0.22μm membrane then determination on the machine.Results:After optimization,pre-processing time only 4 hours.The minimum detection limit is 0.004 μg/L,the linear equation: Y=2.13e+003X+9.09,the correlation coefficient is 0.9996,the recovery rate is in the range of 75.8%～104.5,the average recovery rate is 86.3%,RSD 3.5%(n=6).Conclusion:This method can rapidly and accurately detect microcystin-LR in drinking water.

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What this paper is about

Objective:To establish a rapid,accurate method detection microcystin-LR in drinking water.Methods:Using the m/z 498.4/135.0 for ions to establish the MRM method.After the water boil 30 minutes,using C18 solid phase extraction column to extract and purify then using 5 ml 0.1% formic acid methanol solution to elute,dried by nitrogen then constant volume to 1ml,pass the 0.22μm membrane then determination on the machine.Results:After optimization,pre-processing time only 4 hours.The minimum detection limit is 0.004 μg/L,the linear equation: Y=2.13e+003X+9.09,the correlation coefficient is 0.9996,the recovery rate is in the range of 75.8%～104.5,the average recovery rate is 86.3%,RSD 3.5%(n=6).Conclusion:This method can rapidly and accurately detect microcystin-LR in drinking water.

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Available abstract

Objective:To establish a rapid,accurate method detection microcystin-LR in drinking water.Methods:Using the m/z 498.4/135.0 for ions to establish the MRM method.After the water boil 30 minutes,using C18 solid phase extraction column to extract and purify then using 5 ml 0.1% formic acid methanol solution to elute,dried by nitrogen then constant volume to 1ml,pass the 0.22μm membrane then determination on the machine.Results:After optimization,pre-processing time only 4 hours.The minimum detection limit is 0.004 μg/L,the linear equation: Y=2.13e+003X+9.09,the correlation coefficient is 0.9996,the recovery rate is in the range of 75.8%～104.5,the average recovery rate is 86.3%,RSD 3.5%(n=6).Conclusion:This method can rapidly and accurately detect microcystin-LR in drinking water.

Key concepts: Chemistry, Chromatography, Formic acid, Microcystin, Detection limit, Tap water, Elution, Extraction (chemistry)

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