2014•Zhonghua laonian xin-nao-xueguanbing zazhiRequires access

Expression of BDNF and TrkB protein in post-stroke depression rats

Li Yu

Abstract

Objective To study the expression of BDNF and TrkB protein in post-stroke depression(PSD)rats and its role in pathogenesis of PSD.Methods Twenty-four adult SD rats were randomly divided into normal control group,depression group,stroke group and model group(6in each group).A rat focal cerebral ischemia model was established by Longa occlusion and a rat PSD model was induced by chronic unpredicted moderate stress and separate breeding.Expression of BDNF and TrkB positive cells was detected by immunohistochemistry on day 29.Results The number of BDNF-positive cells was significantly less in PSD model group than in normal control group and depression group(P0.05).The number of TrkB-positive cells was significantly less in PSD model group than in normal control group,stroke group and depression group(P0.01). Conclusion The down-regulated expression of BDNF and TrkB protein in PSD rats is related with the pathogenesis of PSD.

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Key concepts: Tropomyosin receptor kinase B, Pathogenesis, Medicine, Depression (economics), Post-stroke depression, Internal medicine, Immunohistochemistry, Stroke (engine)