Protective effects of propofol on endotoxin-induced shock in rabbits

Objective To study the protective effects of propofol in different doses on e ndotoxin-induced shock in rabbits. Methods Edotoxin shock was replicated by continuous infusion o f E-coli lipopolysachaide(LPS O111B4)in rabbits.F ifty New Zealand rabbits, male or female, were randomly divided into 5 groups : norm al control group(group A),endotoxin shock control group(group B),propofol infu sio n (2mg·kg~-1·h~-1)(group C),propofol infusion (5mg·kg~-1 · h~-1)(group D),propofol infusion (10mg·kg~-1·h~-1)(group E). Group C,D,E received a continuous infusion of propofol for 30min afte r intravenous LPS. The animals were observed for 5 hours after LPS. MAP,PaO_2 ,pH and serum TNF-α concentrations were recor ded every hour after LPS. The survival rates of the animals in all groups duri ng 48 hours after LPS were compared. Results Compared to group B,propofol a ttenuated significantly the decrease in MAP and increase in serum content s of TNF-α in group C,D and E. The 48 hour survival rate was also significant ly higher in propofol groups(group C,D,E). The protective effect was better in group D compared with that in group C and E. Conclusion Propofo l has a protective effect on endotoxin-induced shock in r abbits. Different dose of propofol has different effect, which is not positivel y correlated with the dosage.