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2007•Unpublished venueRequires access

Expression of EGFR protein in oral lichen planus

Xiaolin Song

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Abstract

Objective To investigate the pathogenesis and carcinogenesis of oral lichen planus (OLP). Methods The expression of EGFR was observed in 10 cases of normal oral mucosa, 16 cases of normal OLP,10 cases of OLP with dysplasia and 14 cases of oral squamous cell carcinoma(OSCC) by immunohistochemical evaluation. Results The expression of EGFR in OLP with dysplasia was significantly higher than that with normal oral mucosa(P0.05). The expression of EGFR in OSCC was significantly higher than that in normal oral mucosa and OLP(P0.01). Conclusion The overexpression of EGFR may play an important role in OLP development and progression.

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What this paper is about

Objective To investigate the pathogenesis and carcinogenesis of oral lichen planus (OLP). Methods The expression of EGFR was observed in 10 cases of normal oral mucosa, 16 cases of normal OLP,10 cases of OLP with dysplasia and 14 cases of oral squamous cell carcinoma(OSCC) by immunohistochemical evaluation. Results The expression of EGFR in OLP with dysplasia was significantly higher than that with normal oral mucosa(P0.05). The expression of EGFR in OSCC was significantly higher than that in normal oral mucosa and OLP(P0.01). Conclusion The overexpression of EGFR may play an important role in OLP development and progression.

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Available abstract

Objective To investigate the pathogenesis and carcinogenesis of oral lichen planus (OLP). Methods The expression of EGFR was observed in 10 cases of normal oral mucosa, 16 cases of normal OLP,10 cases of OLP with dysplasia and 14 cases of oral squamous cell carcinoma(OSCC) by immunohistochemical evaluation. Results The expression of EGFR in OLP with dysplasia was significantly higher than that with normal oral mucosa(P0.05). The expression of EGFR in OSCC was significantly higher than that in normal oral mucosa and OLP(P0.01). Conclusion The overexpression of EGFR may play an important role in OLP development and progression.

Key concepts: Oral lichen planus, Oral mucosa, Immunohistochemistry, Dysplasia, Carcinogenesis, Medicine, Basal cell, Epithelial dysplasia

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