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The expression of NF-κ B in brain neuronal cell after cardiopulmonary resuscitation in rats

Zhaofen Lin

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Abstract

Objective To investigate the expression of NF-κB in brain neuronal cell after cardiopulmonary resuscitation in rats.Methods Caridiac arrest model was induced by asphyxiation with ice-cold 0.5 mol Kcl in rats.Cardiopulmonary resuscitation were given 5 minutes after arrest.28 Sprague Dawley rats were randomly divided into 5 groups:control group(n=4)and 4 experimental group(n=6).NF-κB protein expression in the rats brain was measured by immunocytochemistry at 3,6,12 and 24 h after resusciation.Results NF-κB protein expression first appeared at 6 h,and remained to 24 h.There existed NF-κ B positive cells around hippocampal.Conclusion NF-κB expression has both protection and in jury effects on neuronal cells after global ishcemia-reperfusion in rats.

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Objective To investigate the expression of NF-κB in brain neuronal cell after cardiopulmonary resuscitation in rats.Methods Caridiac arrest model was induced by asphyxiation with ice-cold 0.5 mol Kcl in rats.Cardiopulmonary resuscitation were given 5 minutes after arrest.28 Sprague Dawley rats were randomly divided into 5 groups:control group(n=4)and 4 experimental group(n=6).NF-κB protein expression in the rats brain was measured by immunocytochemistry at 3,6,12 and 24 h after resusciation.Results NF-κB protein expression first appeared at 6 h,and remained to 24 h.There existed NF-κ B positive cells around hippocampal.Conclusion NF-κB expression has both protection and in jury effects on neuronal cells after global ishcemia-reperfusion in rats.

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Available abstract

Objective To investigate the expression of NF-κB in brain neuronal cell after cardiopulmonary resuscitation in rats.Methods Caridiac arrest model was induced by asphyxiation with ice-cold 0.5 mol Kcl in rats.Cardiopulmonary resuscitation were given 5 minutes after arrest.28 Sprague Dawley rats were randomly divided into 5 groups:control group(n=4)and 4 experimental group(n=6).NF-κB protein expression in the rats brain was measured by immunocytochemistry at 3,6,12 and 24 h after resusciation.Results NF-κB protein expression first appeared at 6 h,and remained to 24 h.There existed NF-κ B positive cells around hippocampal.Conclusion NF-κB expression has both protection and in jury effects on neuronal cells after global ishcemia-reperfusion in rats.

Key concepts: Medicine, Cardiopulmonary resuscitation, Immunocytochemistry, Resuscitation, NF-κB, Hippocampal formation, Protein expression, Internal medicine

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