The influence and curative effect of montelukast on plasma level of cytokines of asthma children

Objective To explore the influence and curative effect of montelukast on plasma level of inflammatory cytokines of asthma child.Methods Sixty-eight asthma children during acute attack were divided into two groups as treatment group and control group.All the children got fundamental treatment as anti-infection,cough-relieving,sputum-reducing,asthma-relieving and hormone-aerosol-inhalation.And the children of treatment group got extra treatment as taking montelukast sodium chewable tablets 5mg per time,once a day,for 8 weeks.The plasma levels of TNF-α,IL-5,IL-8,IL-10 and the clinic curative effect and adverse reaction were observed,and so were the recurrence rate within half a year and within a year.Results The plasma levels of TNF-α,IL-5 and IL-8 descended significantly comparing with 8 weeks before treatment,but the level of IL-10 was the opposite(P 0.05 or P 0.01),and the rangeability of treatment group was more significantly obviously than that of control group(P 0.05).The total clinic effective rate of treatment group was significantly higher than that of control group(χ2 =6.48,P 0.05).No obviously reverse reaction was found during the therapy period of both the two groups.Half a year and one year after treatment,the recurrence rate of treatment group were significantly lower than that of control group(χ2 =6.44 and 6.13,P 0.05).Conclusion Treating asthma children with montelukast shows safe,effective and low-recurrence rate.Montelukast is an ideal drug to treat and prevent children asthmatic attack.Maybe its mechanism was related with regulating the levels of plasma cytokines.