Relationship between cerebral infarction and paraoxonase 1 gene-162A/G polymorphism

Objective To study the relationship between paraoxonase-1(PON1) gene-162A/G polymorphism and cerebral infarction(CI) in Han people in Shanghai area.Methods The study population comprised of 126 CI patients and 131 control subjects.Genotyping of PON1-162A/G was determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique.Results The distribution of AA,AG and GG genotypes of PON1 gene was 22.14%,19.08% and 58.78% in control group,and 23.81%,37.30% and 38.89% in CI group,respectively.The frequency of allelic A and G was 31.68% and 68.32% in control group,and 42.46% and 57.54% in CI patients,respectively.The differences of genotype and allelic frequency of PON1-162A/G were statistically significant between these two groups(P0.05).Odds ratio of allele A was 1.5914 with 95% confidence interval 1.1095-2.2828 in CI group as compared with control group.Conclusion The PON1 gene-162A/G polymorphism might be associated with cerebral infarction in Han people in Shanghai area.