A clinical analysis on the recurrence prevention effect of mifepristone after myomectomy

Objective To analyse the recurrence prevention effect of mifepristone after myomectomy.Methods145 cases underwent laparotomy myomectomy in our department from Jul,2005 to Jun,2008 were analyzed with retrospective cohort study.86 patients received mifepristone postoperative(mifepristore group)and the other 59 patients without mifepristone taking(control group).ResultsThe number of myoma and diameter of the largest myoma were all not differ much between the two groups(P0.05).The average follow-up were 25.8±8.1 months and(22.5±7.1)months.The recurrence rates of the mifepristone group and the control were 16.3% and 27.1%(P=0.113).The average time of recurrence of mifepristone group was later than control group(10.9±4.6)months vs(7.2±3.1)months,P0.05).Multiple factor analysis showed that the number of myoma was the most important factor related with the recurrence(P0.001).There were no serious side effect in the mifepristone group.ConclusionsMifepristone could retard the recurrence after myomectomy to some degree.But there were some side effect.The most important factor to reduce the recurrence rate was to find and remove the myomas completely.