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2010•Journal of Chengdu Medical CollegeRequires access

The application of gel microcolumn assay in the detection of IgG antibodies in pregnant women

HE Feng-e

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Abstract

Objective To compare the gel microcolumn assay and the conventional tube test for IgG antiA(B) titration .Methods A total of 364 blood samples of O group pregnant women with non O group husbands were detected simultaneously by the conventional tube test and the gel microcolumn assay. Results The geometric mean of anti-A(B) IgG titers with the gel microcolumn assay was significantly higher than that of conventional one. The differences were significant (t=18.15,t=15.81; P0.001). The positive rate of anti-A(B) IgG titers with the gel microcolumn was significantly higher than that of conventional one (χ2=21.5688,χ2=13.7898; P0.001). The correlation coefficient was 0.8485 and 0.8499,respectively. Conclusion The gel microcolumn assay is more sensitive than classic method,and it is necessary to rebuild reference values of clinical significance.

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What this paper is about

Objective To compare the gel microcolumn assay and the conventional tube test for IgG antiA(B) titration .Methods A total of 364 blood samples of O group pregnant women with non O group husbands were detected simultaneously by the conventional tube test and the gel microcolumn assay. Results The geometric mean of anti-A(B) IgG titers with the gel microcolumn assay was significantly higher than that of conventional one. The differences were significant (t=18.15,t=15.81; P0.001). The positive rate of anti-A(B) IgG titers with the gel microcolumn was significantly higher than that of conventional one (χ2=21.5688,χ2=13.7898; P0.001). The correlation coefficient was 0.8485 and 0.8499,respectively. Conclusion The gel microcolumn assay is more sensitive than classic method,and it is necessary to rebuild reference values of clinical significance.

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Available abstract

Objective To compare the gel microcolumn assay and the conventional tube test for IgG antiA(B) titration .Methods A total of 364 blood samples of O group pregnant women with non O group husbands were detected simultaneously by the conventional tube test and the gel microcolumn assay. Results The geometric mean of anti-A(B) IgG titers with the gel microcolumn assay was significantly higher than that of conventional one. The differences were significant (t=18.15,t=15.81; P0.001). The positive rate of anti-A(B) IgG titers with the gel microcolumn was significantly higher than that of conventional one (χ2=21.5688,χ2=13.7898; P0.001). The correlation coefficient was 0.8485 and 0.8499,respectively. Conclusion The gel microcolumn assay is more sensitive than classic method,and it is necessary to rebuild reference values of clinical significance.

Key concepts: Titer, Chromatography, Titration, Chemistry, Antibody, Significant difference, Molecular biology, Medicine

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