Preparation and Release of Minocycline Hydrophilic Gel Sustained-release Matrix Tablets

OBJECTIVE:To prepare Minocycline Hydrophilic Sustained-release Matrix Tablets(MHSMT) and determine their release rate in vitro.METHODS:MHSMT were prepared by direct compression process and the drug release was determined by ultraviolet spectrophotometry.The effects of different specification and amount of HPMC and different releasing conditions on drug release from the matrix tablets were observed.RESULTS:The preparation was yellow tablets with its property up to the standard specified in Chinese Pharmacopeia(2005 edition).32% HPMC K100 was proved to be the optimal sustained-release matrix material.Different release media and the releaser had significant effects on drug release.The release behavior was in line with Higuchi equation.CONCLUSIONS:This preparation process of the tablets is simple,and the method for the determination of drug release is accurate and feasible.The tablets had remarkable sustained-release property in vitro.