Effect of Naoling decoction on TGFβ1 expression in rats with Alzheimer disease

Objective To investigate the effect of Nao-ling Decoction to the expression of TGFβ1. Method The AD model was prepared by the injection of Aβ1-42 into the dorsal of double sides of hippocampus. Their ability of learning and memory was detected by Y-maze,the deposition of β-amyloid protein in model rats group CA3 hippocampus sector was shown by Congo red stain,the expression of TGF-β1 in the hippocampus was measured with immunohistochemical stain. Result The Nao-ling Decoction can improve the the learning and memory of AD model rats ,and the expression of TGF-β1 in the Nao-ling Decoction was much higher than those AD model rats. Conclusion The Nao-ling Decoction enhance the expression of TGF-β1,so as to reduce the deposition of β-amyloid protein in model rats and improve the learning and memory of the AD rats.