ScholarLens Back to search
2004•Strait Pharmaceutical JournalRequires access

Determination of the Ranitidine's Content and the Related Substances of Compound Ranitidine Capsules by HPLC

LU Jian-hui

Open publisher page 0 citations

Abstract

OBJECTIVE To establish a HPLC method to determine the ranitidine's content and the related substances of compound ranitidine capsules.METHODS C_ 18 column(4.6mm×250mm,5μm)was used under room tempretune.The mobile phase was consisted of acetonitrile-0.05mol·L -1 lemon acid solution(adjusted pH to 3.5 with triethylamine)(15∶85).The detection wavelength was set at 314nm.The flow rate was 1.0mL·min -1 and injection volume was 10μL.RESULTS The calibration curves of ranitidine was linear in the range of 80～320μg·mL -1 (r=0.9999).The average recoveries were 100.1%,RSD=1.2%.CONCLUSION This method is Sensitive,accurate,quick and simple.

About this research paper

What this paper is about

OBJECTIVE To establish a HPLC method to determine the ranitidine's content and the related substances of compound ranitidine capsules.METHODS C_ 18 column(4.6mm×250mm,5μm)was used under room tempretune.The mobile phase was consisted of acetonitrile-0.05mol·L -1 lemon acid solution(adjusted pH to 3.5 with triethylamine)(15∶85).The detection wavelength was set at 314nm.The flow rate was 1.0mL·min -1 and injection volume was 10μL.RESULTS The calibration curves of ranitidine was linear in the range of 80～320μg·mL -1 (r=0.9999).The average recoveries were 100.1%,RSD=1.2%.CONCLUSION This method is Sensitive,accurate,quick and simple.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

OBJECTIVE To establish a HPLC method to determine the ranitidine's content and the related substances of compound ranitidine capsules.METHODS C_ 18 column(4.6mm×250mm,5μm)was used under room tempretune.The mobile phase was consisted of acetonitrile-0.05mol·L -1 lemon acid solution(adjusted pH to 3.5 with triethylamine)(15∶85).The detection wavelength was set at 314nm.The flow rate was 1.0mL·min -1 and injection volume was 10μL.RESULTS The calibration curves of ranitidine was linear in the range of 80～320μg·mL -1 (r=0.9999).The average recoveries were 100.1%,RSD=1.2%.CONCLUSION This method is Sensitive,accurate,quick and simple.

Key concepts: Ranitidine, Chromatography, Chemistry, High-performance liquid chromatography, Calibration curve, Triethylamine, Content determination, Linear range

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Determination of the Ranitidine's Content and the Related Substances of Compound Ranitidine Capsules by HPLC — Research Paper | ScholarLens