Changes of microalbuminuria and serum high molecular weight-adiponectin in hypertensive patients with metabolic syndrome

Objective To compare the differences of microalbuminuria(MAU) and serum high molecular weight-adiponectin( HMW-ADP) between essential hypertensive patients and hypertensive patients with metabolic syndrome (MS),and to explore the association of MAU and HMW-ADP in hypertensive patients with MS. Methods 68 essential hypertensive patients were enrolled and divided into two groups by the definition of MS: the MS and hypertension group (n = 33) and the pure hypertension group (n = 35). The urine albumin-to-creatinine ratio(ACR) was measured by radioimmunoassay. Serum HMW-ADP was determined by sandwich ELISA. Results The MAU level was higher and the level of serum HMW-ADP was lower in the MS and hypertension group than in the hypertension group(P 0. 01). Pearson correlation analysis showed that HMW-ADP was not correlated with ACR(P 0. 05). Binary logistic regression showed that fasting plasma glucose,high density lipoprotein cholesterol,triglyceride,low density lipoprotein cholesterol,ACR and HMW-ADP were associated with the development of MS in hypertensive patients( P 0. 05-0. 01). Conclusions MS aggravates kidney damage in hypertensive patients. HMW-ADP is not correlated with ACR. Increase of ACR and decrease of HMW-ADP promote development of MS in patients with hypertension.