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2008•The Chinese Journal of Modern Applied PharmacyRequires access

Determine the chloramphenicol in chloramfenicol eye drops by the first order derivative spectrophotometry

Zhao Jia-tai

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Abstract

OBJECTIVE To establish a method to determine the content of Chloramphenicol eye drops.METHODS The first order derivative spectrophotometry was used to determine the chloramphenicol in chloramfenicol eye drops without separation.The detecting wavelengh was set at 300 nm. RESULTS The method was linear within the range of 8～64 mg·L-1,r=0.999 8.The average recovery of chloramphenicol was 99.9﹪ and RSD was 1.2﹪.CONCLUSION The interference of the other components can be excluded by this method,which is simple,rapid.It is suitable for the quality control of Chloramphenicol eye drops.

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What this paper is about

OBJECTIVE To establish a method to determine the content of Chloramphenicol eye drops.METHODS The first order derivative spectrophotometry was used to determine the chloramphenicol in chloramfenicol eye drops without separation.The detecting wavelengh was set at 300 nm. RESULTS The method was linear within the range of 8～64 mg·L-1,r=0.999 8.The average recovery of chloramphenicol was 99.9﹪ and RSD was 1.2﹪.CONCLUSION The interference of the other components can be excluded by this method,which is simple,rapid.It is suitable for the quality control of Chloramphenicol eye drops.

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Available abstract

OBJECTIVE To establish a method to determine the content of Chloramphenicol eye drops.METHODS The first order derivative spectrophotometry was used to determine the chloramphenicol in chloramfenicol eye drops without separation.The detecting wavelengh was set at 300 nm. RESULTS The method was linear within the range of 8～64 mg·L-1,r=0.999 8.The average recovery of chloramphenicol was 99.9﹪ and RSD was 1.2﹪.CONCLUSION The interference of the other components can be excluded by this method,which is simple,rapid.It is suitable for the quality control of Chloramphenicol eye drops.

Key concepts: Chloramphenicol, Chromatography, Spectrophotometry, Derivative (finance), Second derivative, Chemistry, Mathematics, Antibiotics

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