Effects of Wumai Danghuang Oral Liquid on Immune Function of Radiation Damage Model Mice

OBJECTIVE:To study the effects of Wumai Danghuang oral liquid on immune function of irradiation damage model mice. METHODS:40 mice were randomly divided into normal control group(constant volume of normal saline),model group(constant volume of normal saline),Wumai Danghuang oral liquid high-dose and low-dose groups(14.6 g/kg,7.3 g/kg). They were given relevant medicines intragastrically once a day for consecutive 14 days. The irradiation damage model was induced by general irradiation with60Co γ-rays,dose rate of 0.667 Gy/min and total dose of 2.0 Gy 2 h after 7 days administration. The number of WBC,spleen index,thymus index,the ability of lymphocytes transformation were examined. RESULTS:Compared with normal control group,the number of WBC,spleen index,the ability of lymphocytes transformation in model group were decreased significantly(P0.01). Compared with Wumai Danghuang oral liquid group,the number of WBC,viscera index,the ability of lymphocyte transformation in Wumai Danghuang oral liquid low-dose and high-dose groups were increased significantly(P0.01 or P 0.05),thymusin index in Wumai Danghuang oral liquid high-dose groups were increased significantly(P0.05).CONCLUSIONS: Wumai Danghuang oral liquid has protective effects on immune function of irradiation damage model mice.