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2005•Journal of Zhejiang University of TechnologyRequires access

New process for 5-nitrosalicylic acid

Gao Jian-rong

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Abstract

The process of synthesizing 5-nitrosalicylic acid by nitration and hydrolysis of o-chlorobenzoic acid was developed and investigated. The influences of the nitration of temperature, proportion of mixed acid and of the hydrolysis of temperature, reaction time were investigated. The yield of nitration was 95.7% with a mixed acid of nitric acid∶sulfuric acid=9∶1, in the course of 0 ℃ and 8h, and the yield of hydrolysis was 98.3% in the course of 140 ℃ and 16 h. The final product (HPLC≥99.8%) was obtained after recrystallizing by the proper ethanol solution.

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What this paper is about

The process of synthesizing 5-nitrosalicylic acid by nitration and hydrolysis of o-chlorobenzoic acid was developed and investigated. The influences of the nitration of temperature, proportion of mixed acid and of the hydrolysis of temperature, reaction time were investigated. The yield of nitration was 95.7% with a mixed acid of nitric acid∶sulfuric acid=9∶1, in the course of 0 ℃ and 8h, and the yield of hydrolysis was 98.3% in the course of 140 ℃ and 16 h. The final product (HPLC≥99.8%) was obtained after recrystallizing by the proper ethanol solution.

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Available abstract

The process of synthesizing 5-nitrosalicylic acid by nitration and hydrolysis of o-chlorobenzoic acid was developed and investigated. The influences of the nitration of temperature, proportion of mixed acid and of the hydrolysis of temperature, reaction time were investigated. The yield of nitration was 95.7% with a mixed acid of nitric acid∶sulfuric acid=9∶1, in the course of 0 ℃ and 8h, and the yield of hydrolysis was 98.3% in the course of 140 ℃ and 16 h. The final product (HPLC≥99.8%) was obtained after recrystallizing by the proper ethanol solution.

Key concepts: Nitration, Nitric acid, Sulfuric acid, Hydrolysis, Yield (engineering), Chemistry, Acid hydrolysis, Ethanol

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