ScholarLens Back to search
2008•Journal of Internal Intensive MedicineRequires access

Changes of Endogenous CO and NO in Rats With Paraquat Induced Lung Injury

Yuteng Ma

Open publisher page 0 citations

Abstract

Objective:To investigate the effect of endogenous CO and NO in rats with paraquat induced lung injury.Methods: The injured lung tissue was studied by HE staining and plasma MDA concentration was detected to evaluate the severity of lung injury.Level of TNF-α was detected.The content of CO,NO and the activity of iNOS in the lung tissue was determined.The expression of HO-1 and iNOS protein was detected by Western Blot.Results: The degree of lung injury was serious obviously after paraquat poisoning.The content of MDA and level of TNF-α elevated significantly.After treatment with hemin,the content of CO increased,but the activity of iNOS and the content of NO decreased.Conclusion: Endogenous CO and NO in lung tissue were increased in rats with paraquat induced lung injury.The level of CO was increased and NO was decreased after treated with hemin,and it might lessened the parauqat induced acute lung injury of rats.

About this research paper

What this paper is about

Objective:To investigate the effect of endogenous CO and NO in rats with paraquat induced lung injury.Methods: The injured lung tissue was studied by HE staining and plasma MDA concentration was detected to evaluate the severity of lung injury.Level of TNF-α was detected.The content of CO,NO and the activity of iNOS in the lung tissue was determined.The expression of HO-1 and iNOS protein was detected by Western Blot.Results: The degree of lung injury was serious obviously after paraquat poisoning.The content of MDA and level of TNF-α elevated significantly.After treatment with hemin,the content of CO increased,but the activity of iNOS and the content of NO decreased.Conclusion: Endogenous CO and NO in lung tissue were increased in rats with paraquat induced lung injury.The level of CO was increased and NO was decreased after treated with hemin,and it might lessened the parauqat induced acute lung injury of rats.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To investigate the effect of endogenous CO and NO in rats with paraquat induced lung injury.Methods: The injured lung tissue was studied by HE staining and plasma MDA concentration was detected to evaluate the severity of lung injury.Level of TNF-α was detected.The content of CO,NO and the activity of iNOS in the lung tissue was determined.The expression of HO-1 and iNOS protein was detected by Western Blot.Results: The degree of lung injury was serious obviously after paraquat poisoning.The content of MDA and level of TNF-α elevated significantly.After treatment with hemin,the content of CO increased,but the activity of iNOS and the content of NO decreased.Conclusion: Endogenous CO and NO in lung tissue were increased in rats with paraquat induced lung injury.The level of CO was increased and NO was decreased after treated with hemin,and it might lessened the parauqat induced acute lung injury of rats.

Key concepts: Paraquat, Lung, Hemin, Medicine, Endogeny, Western blot, Pathology, Immunohistochemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Changes of Endogenous CO and NO in Rats With Paraquat Induced Lung Injury — Research Paper | ScholarLens