2002•Chinese New Drugs JournalRequires access

A double-blind and double-dummy comparative study of quetiapine and chlorpromazine in the treatment of schizophrenia

Jing Bo Zhao

Abstract

Objective:To evaluate the efficacy and safety of quetiapine for treatment of schizophrenia.Methods:221 cases of schizophrenic patients were randomly divided into quetiapine group( n =114) and chlorpromazine group( n =107), and treated for eight weeks.The PANSS was adopted for evaluating therapeutic effects.Results:The total effective rates in quetiapine and chlorpromazine group were simillar,with no significant difference.Less adverse reactions were found in quetiapine group.Conclusion:The domestic quetiapine is an effective and safe agent for treatment of schizophrenia.

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Key concepts: Quetiapine, Chlorpromazine, Schizophrenia (object-oriented programming), Medicine, Adverse effect, Significant difference, Double blind, Quetiapine Fumarate