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2006•Zhongguo Yike Daxue xuebaoRequires access

Anti-tumor activity of curcumin-related compounds

Wang Yu-ling

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Abstract

Objective: To study the HeLa cell apoptosis induced by curcumin-related compounds and the activity-structure relationship of this compound.Methods: MTT method,morphological observation,agarose gel electrophoresis were performed in this study.Results: Curcumin-related compounds inhibited the growth and induced the apoptosis of HeLa cells.Marked morphological changes,including condensed chromatin,nuclear fragmentation,apoptotic bodies,and DNA ladder in agarose gel,were observed.Conclusion: Curcumin-related compounds could inhibit the apoptosis of HeLa cells,which is correlated with its structure.

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What this paper is about

Objective: To study the HeLa cell apoptosis induced by curcumin-related compounds and the activity-structure relationship of this compound.Methods: MTT method,morphological observation,agarose gel electrophoresis were performed in this study.Results: Curcumin-related compounds inhibited the growth and induced the apoptosis of HeLa cells.Marked morphological changes,including condensed chromatin,nuclear fragmentation,apoptotic bodies,and DNA ladder in agarose gel,were observed.Conclusion: Curcumin-related compounds could inhibit the apoptosis of HeLa cells,which is correlated with its structure.

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Available abstract

Objective: To study the HeLa cell apoptosis induced by curcumin-related compounds and the activity-structure relationship of this compound.Methods: MTT method,morphological observation,agarose gel electrophoresis were performed in this study.Results: Curcumin-related compounds inhibited the growth and induced the apoptosis of HeLa cells.Marked morphological changes,including condensed chromatin,nuclear fragmentation,apoptotic bodies,and DNA ladder in agarose gel,were observed.Conclusion: Curcumin-related compounds could inhibit the apoptosis of HeLa cells,which is correlated with its structure.

Key concepts: HeLa, Curcumin, Apoptosis, Agarose gel electrophoresis, DNA fragmentation, Agarose, Fragmentation (computing), Chemistry

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