Clinical Efficacy of Chinese Herbal Medicine Plus Alprostadil for Treatment of Chronic Renal Failure

Objective:The investigation on the clinical efficacy and safety of Chinese herbal medicine plus alprostadil for the treatment of chronic renal failure. Methods :Seventy CRF patients were randomly divided into control group and treatment group. The control group was given alprostadil injection on the basis of conventional treatment,and the treatment group was given Chinese herbal medicine Quyuxiezhuo recipe based on the treatment for the control group. Before and after treatment, clinical symptoms, serum creatinine,blood urea nitrogen,blood uric acid and creatinine clearance rate as well as the incidence of adverse reaction in the two groups were recorded. Results :After treatment,the total effective rate was 61.76% in the control group and was 86.11% in the treatment group(P 0.05). Serum creatinine level was decreased in both groups(P 0.05 compared with that before treatment),and the decrease was obvious in the treatment group(P 0.05). Creatinine clearance rate was improved than before the treatment in treatment in treatment group(P 0.05). No severe adverse reaction was found in the two groups. Conclusion:Chinese herbal medicine plus alprostadil is effective and safe for the treatment of chronic renal failure,and can postpone the progress of renal failure.