Effect of estrogen on the contents of MDA and EAA in contex of male rats during cerebral ischemia and reperfusion

Objective To study the effects of estrogen on the contents of EAA in cortex of male rats during cerebral ischemia and reperfusion. Methods Adult male SD rats weighing 240～280g were matched completely randomly. We made the local cerebral ischemic reperfusion model with thread embolism of left middle cerebral artery(MCA)of male rats. Rats were treated with estrogen after MCA occlusion by intrapertoneal injected. The animals were killed until the scheduled time of the death. Then we determined the ischemic changes of cerebral infarction size and the contents of GLU,ASP and GABA. Results The cerebral infaction size in estrogen group were significantly lower than in ischemic group. The contents of GLU and ASP were significantly higher in the ischemic group compared with estrogen treated group. Conclusion Estrogen exerts neuroprotective effects when administered after cerebral ischemic reperfusion in male rats. The possible protective mechanism is that estrogen can mediate the productive of EAA.