Analysis of bacterial resistance in Chang′an district of Xi′an province

Objective To investigate bacterial resistance of clinical isolated strains from Xi′an Chang′an area,and to learn the feature of bacterial resistance in this area.Methods Microporous plate dilution method was used to study the bacterial drug resistance.Resistant,inter mediate and sensitive were determined according to CLSI criterion.1 260 pathogenic strains wered isolated from our hospital during Jun 2008 to Nov 2010.Results The detectable rates of methicillin-resistant staphy lococals aureus(MRSA) and methicillin resistant staphy lococcus epidermidis(MRSE) were 47.7% and 72%,respectively.Of 1260 clinical isolates,gram negative bacilli and gram positive cocci accounted for 60% and 40%,respectively,The prevalence of ESBLs-producing strains in Enterobacter coli and klebsiella spp.isotales was 48.1%,44.7%,respectively.Against all the ESBLs strains in Enterobacter coli and klebsicllla spp,meropenem,imipenem,cefoperazone/sulbactan cefepime showed the lowest resistant rates(21.4%,26.5% and 25.1%).Isolatws of Pseudomonas aeruginosa were resistant to efperazone/sulbactam,meropenem,imipenem,The resistance rates of Acinetobacter spp.to cefoperazone/sulbactam and meropenem imipenem were 2.9% 1.8% and 5.2%,respectively.Some pandrug resistant bacteria were found of Pseudomonas aeruginosa(4.8%)and Acinetobacter baumannic(2.11%).The new fluroquinolones,levofloxacin showecl strong and broad spectrum activity against the most gram-positive and gram-negative bacteria.Conclusion The detection rates of ESBLs strains in Enterobacter coli and Klebsiella spp.are higher in Xi′an area.The increase of separation rates of non-fermentative Gram-negative bacilli and the emerging bacterial resistance,and pandrug resistance in pseudomonas aeruginosa and Acinetobacter baumannii warrants further enhancing the local surveillance of bacterial resistance and characterization of panresistance mechanism to inform the rational use of antimicrobial agents and containment of bacterial resistance.