Observation on curative effect of puerarin injection(葛根素注射液) combined with astragalus injection(黄芪注射液) on heart failure in 110 patients with ischemic heart disease

Objective: To observe the shortterm effect of puerarin injection(葛根素注射液) combined with astragalus injection(黄芪注射液) on heart failure in patients with ischemic heart disease.Methods: Two hundred and twenty heart failure patients with ischemic heart disease were randomly divided into two groups.The control group was treated with conventional treatment,including angiotensinconverting enzyme(inhibitor)(ACEI),digitalis,diuretic and vasodilators.The treatment group was treated with the same(therapy) as that in the control group,except vasodilator such as digitalis,isosorbide dinitrate,glonoin,and was(additionally) administered puerarin injection 500 ml combined with astragalus injection 40 ml for intravenous drip.Ten days were a therapeutic course and the patients were treated for courses in both groups.The(cardiac)(function) such as heart rate(HR),cardiac output(CO),left ventricular ejection fraction(LVEF) and left(ventricular) enddiastolic pressure(LVEDP),grade of cardiac function,clinical(symptoms) and signs(before) and after treatment,as well as the sideeffects of medicine were observed.Results: The clinical(symptoms),signs,CO,LVEF were improved in the treatment group,the differences were significant(compared) to the(control) group(P0.05 or P0.01).The incidence rates of sideeffect and toxic reaction in the treatment(group)(8.2% and 0) were significantly lower than those of the control group(23.6% and 14.5%,P0.05(and P0.01)). (Conclusion): Puerarin injection combined with astragalus injection for(treatment) of heart(failure) in(patients) with ischemic(heart)(disease) shows a significant shortterm effect without sideeffects.