Granular Cell Tumor (GCT)of the Breast:A Clinical Pathologic Analysis of 2 Cases

Objective To study the histopathological characteristics,diagnosis,differential diagnosis and prognosis of Granular cell tumor of the breast. Methods Two cases of Granular cell tumor of the breast were studied by histopathological observation and immunohistochemical staining. Results No special clinical situations were found in two cases and the tumor was charsterized by clear cell boundary,aboundant cytoplasm, full of acidophilic granules and it also infiltrated beyond the edge of the main tumor. Immunohistochemical study demonstrated that tumor cells were reacted with S-100,NSE but negatively with CEA. Those benign ones do not metastasize and such patients have favorable prognosis. Conclusion GCT of the breast,a rarely tumor that can be misdiagnosed by frozen section,clinical and cytological tests. The disease should be enforced to study and avoid being operated excessively and unnecessarily.