Experimental research on anti-fatigue effect of “Shenwu Capsule”in mice

Objective To study the anti-fatigue effect ofShenwu Capsulein mice and to provide the basis for further development and application. Methods Fifty SPF male mice were randomly divided into five groups: blank control group,positive control group,and high,middle,low doseShenwu Capsulegroups( 900. 0 μg/g,450. 0 μg/g,225. 0 μg/g). The mice were intragastrically administrated for 14 days continuously. Then,the contents of LD,BUN,hepatic glycogen,muscle glycogen,LDH and exhaustive swimming time of mice after exercise were determined by weight loading swimming experiment. Results Compared with blank control group,Shenwu Capsulecould markedly prolong the exhaustive swimming time,increase the contents of hepatic glycogen and muscle glycogen,enhance the activity of LDH,and reduce the concentration of serum BUN( P 0. 05,P 0. 01). Conclusion Shenwu Capsulehas a certain effect on relieving fatigue.