The value of cervical biopsies under colposcopy in the diagnosis of cervical intraepithelial neoplasia

Objective:To evaluate the value of cervical biopsies under colposcopy in the diagnosis of cervical intraepithelial neoplasia.Methods:The clinical and pathological data of 157 patients with all types of CIN diagnosed by colposcopically directed cervical biopsies and then treated with loop electrosurgical excision procedure and(or) cervical conization and(or) hysterectomy in the short term in our hospital from January 2009 to December 2010 were analyzed retrospectively.Results:There were 118 cases(75.2%) of the diagnosis by colposcopically directed cervical biopsies were consistent and 39 cases(24.8%) cases were not consistent with the final diagnosis in 157 cases.The consistence rate of the CINI,II and III by colposcopically directed cervical biopsies and the final diagnosis were 62.9%,77.8%,82.6%,including 18 cases(11.5%)were pathologically diagnosed downgrade,21 cases(13.4%)were pathologically diagnosed upgrades,4 cases(2.5%) diagnosed as invasive cervical cancer.Conclusion:Great attention should be paid to early screening of cervical disease and application of the colposcopically directed cervical biopsies in cervical intraepithelial neoplasia;colposcopy can provide a accurate site for biopsy,increase positive rate of biopsy and reduce the rate of misdiagnosis.Although the colposcopically directed cervical biopsies have a certain proportion of missed diagnosis of invasive cervical cancer,but it is still a convenient,economical,less invasive and reliable method of diagnosis of CIN.