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2006•Guangxi Medical JournalRequires access

Clinical significance and changes of serum TNF-α、IL-6、IL-8 and PAF in severe acute pancreatitis

Chen Guo-h

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Abstract

Objective To study the clinical significance and changes of serum TNF-α、IL-6、IL-8、PAF in patients with severe acute pancreatitis(SAP).Methods Serum TNF-α、IL-6、IL-8、PAF values of all patients were measured by ELISA.50 cases with mild AP(MAP group),50 cases with SAP(SAP group) and 30 non-pancreatitis patients as control in group.Results Serum levels of TNF-α、IL-6、IL-8、PAF in MAP group were significantly increased than in the control group(P0.001); Serum levels of TNF-α、IL-6、IL-8、PAF in SAP group were significantly increased than those of MAP and control group(all P0.001),TNF-α、IL-6、IL-8、PAF were significantly increased in 3 death patients as compared to 47 survivals(all P0.05).Conclusion The determination of serum levels of TNF-α、IL-6、IL-8、PAF and APACHE-Ⅱ score may be served as effective marks to predict the pathogenetic condition and outcome of severe acute pancreatitis.

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Objective To study the clinical significance and changes of serum TNF-α、IL-6、IL-8、PAF in patients with severe acute pancreatitis(SAP).Methods Serum TNF-α、IL-6、IL-8、PAF values of all patients were measured by ELISA.50 cases with mild AP(MAP group),50 cases with SAP(SAP group) and 30 non-pancreatitis patients as control in group.Results Serum levels of TNF-α、IL-6、IL-8、PAF in MAP group were significantly increased than in the control group(P0.001); Serum levels of TNF-α、IL-6、IL-8、PAF in SAP group were significantly increased than those of MAP and control group(all P0.001),TNF-α、IL-6、IL-8、PAF were significantly increased in 3 death patients as compared to 47 survivals(all P0.05).Conclusion The determination of serum levels of TNF-α、IL-6、IL-8、PAF and APACHE-Ⅱ score may be served as effective marks to predict the pathogenetic condition and outcome of severe acute pancreatitis.

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Available abstract

Objective To study the clinical significance and changes of serum TNF-α、IL-6、IL-8、PAF in patients with severe acute pancreatitis(SAP).Methods Serum TNF-α、IL-6、IL-8、PAF values of all patients were measured by ELISA.50 cases with mild AP(MAP group),50 cases with SAP(SAP group) and 30 non-pancreatitis patients as control in group.Results Serum levels of TNF-α、IL-6、IL-8、PAF in MAP group were significantly increased than in the control group(P0.001); Serum levels of TNF-α、IL-6、IL-8、PAF in SAP group were significantly increased than those of MAP and control group(all P0.001),TNF-α、IL-6、IL-8、PAF were significantly increased in 3 death patients as compared to 47 survivals(all P0.05).Conclusion The determination of serum levels of TNF-α、IL-6、IL-8、PAF and APACHE-Ⅱ score may be served as effective marks to predict the pathogenetic condition and outcome of severe acute pancreatitis.

Key concepts: Acute pancreatitis, Medicine, Clinical significance, Gastroenterology, Tumor necrosis factor alpha, Pancreatitis, Internal medicine, Interleukin 6

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