Effects of taurine on left ventricular hypertrophy in renovascular hypertensive rats

AIM To investigate the preventive effects of taurine on the left ventricle hypertrophy in renovascular hypertensive rats. METHODS Two-kidney 1-clip (2K1C) rats were used to establish the model of renovascular hypertension. The myocardial local aldosterone(Ald) and AngⅡconcentration (MDC,MAC) were measured by radioimmunoassay. Expression of oncogene c-fos mRNA was analyzed by means of in situ hybridization. The myocardial collagen concentration (MCC) was measured by biochemical method. The myocardial tissue structure was observed under the microscope ,and the myocardial fiber diamension (MFD) was measured with micrometer. The linear correlation between MCC, MFD and MAC or MDC was analysed respectively. RESULTS Compared with sham operated rats ,the MCC, MAC, MDC and MFD were significantly increased in 2K1C rats ( P 0.01).Expression of oncogene c-fos mRNA was also obviously higher than sham group( P 0.01). Collagenous fiber productive reaction occurred in the circumference of the coronary artery and stretehed to periphery interstitial. Both MCC and MFD positively correlated with MAC and MDC respectively ( P 0.01). Taurine has an obviously suppressive effect on SBP, MAC, MFD ,MCC,LVWI , MDC c-fos mRNA expression( P 0.01 for all these indices), myocardial cell hypertrophy and collagenous fiber productive reaction in 2K1C rats. CONCLUSION Taurine which effectively suppress myocardial cell hypertrophy and collagenous fiber productive reaction by decreasing myocardial local RAAS and c-fos mRNA expression can produce good preventive effect on left ventricle hypertrophy caused by renal hypertension