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Change in tumor necrosis factor α and its clinical significance in patients with diabetes mellitus

Yan Wang

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Abstract

Objectives: This paper was conducted to study the changes in tumor necrosis factor α( TNF α) and its clinial significance in the patients with diabetes mellitus. Methods:Serum TNF α was detected by ELISA method. Results:The levels of TNF α were significantly increased in type 2 diabetic patients and in the group with microangiopathy as compared with controls and in the group without microangiopathy( P 0.05).There was a positive correlation between the TNF α level and triglyceride, insulin, HbA1c in the diabetic patients( P 0.01). Conclusions: It is suggested that TNF α is related to lipid metabolic disorders, insulin resistance and microangiopathy.

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What this paper is about

Objectives: This paper was conducted to study the changes in tumor necrosis factor α( TNF α) and its clinial significance in the patients with diabetes mellitus. Methods:Serum TNF α was detected by ELISA method. Results:The levels of TNF α were significantly increased in type 2 diabetic patients and in the group with microangiopathy as compared with controls and in the group without microangiopathy( P 0.05).There was a positive correlation between the TNF α level and triglyceride, insulin, HbA1c in the diabetic patients( P 0.01). Conclusions: It is suggested that TNF α is related to lipid metabolic disorders, insulin resistance and microangiopathy.

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Available abstract

Objectives: This paper was conducted to study the changes in tumor necrosis factor α( TNF α) and its clinial significance in the patients with diabetes mellitus. Methods:Serum TNF α was detected by ELISA method. Results:The levels of TNF α were significantly increased in type 2 diabetic patients and in the group with microangiopathy as compared with controls and in the group without microangiopathy( P 0.05).There was a positive correlation between the TNF α level and triglyceride, insulin, HbA1c in the diabetic patients( P 0.01). Conclusions: It is suggested that TNF α is related to lipid metabolic disorders, insulin resistance and microangiopathy.

Key concepts: Microangiopathy, Internal medicine, Medicine, Tumor necrosis factor alpha, Insulin resistance, Tumor necrosis factor α, Diabetes mellitus, Clinical significance

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