Soy Isoflavones Lowers Blood Lipid of Atherosclerotic Rat

Objective To study the influ en ce of high quantity of soy isofalvone's on the content of blood li pid in the serum of atherosclerotic rat. Methods 60 Wistar ra ts were randomly divided in 6 groups.Rats of normal diet control gr oup were fed with normal diet,and rats of the remainder groups were fed with hi gh cholesterol(3.5%),high fat (10%)and 1%hyocholicsalt plus 85% normal diet.3 groups of rats of the high fat diet plus low, medium, high dose SI were fed w ith high content of total isoflavones simultaneously.The dosage were 30 mg/(kg ,bw),90 mg/(kg,bw) and 270 mg/(kg,bw)per day.Rats of the high fat diet plus estrobene as control group was given estrobene 0.25 mg/(kg,bw)per day. After 20 week,rats were killed and have the blood lipid detected. Results Soy isoflavones could lower the level of bloo d lipid in the serum of predisposed with high cholesterol and high rat diets. Conclusions The results suggest soy isoflaovnes may inhibit the formation of atherosclerosis through lowering the le vel of blood lipid.