Pathogens detection and drug-resistance analysis in clinical respiratory infections

Objective To analyse the pathogens causing respiratory infection and their drug-resistance to antibiotic drugs for guiding clinical rational drug use and preventing nosocomial infection.Methods The pathogens isolated from the specimens collected in the patients with respiratory infections and the results of drug sensitivity tests from January to December 2009 were summarized and analyzed.Results in 10381 detected specimens,798 pathogenic strains were isolated( taking the first strain in the same patient),including 682 strains of Gram-negative bacteria(85.5%),116 strains of Gram-positive bacteria(14.5%).The Gram-negative bacteria were mainly K.pneumonia,E.coli,P.aeruginosa and A.baumannii.The Gram-positive bacteria were dominated by S.aureus,S.haemolyticusand E.faecalis.ESBLS-producing E.coli,K.pneumonia,K.oxytocum and P.mirabilis were in 60 strains with the positive rate of 55.9%,25.8% and 12.5%.MRSA accounted for 46.0% of staphylococcus aureus.The results of drug sensitivity tests were different with various kinds of bacteria and enzyme-producing and medication should be selected according to the types of bacteria.Conclusion The pathogens of respiratory infection are mainly Gram-negative bacteria and the types are dominated by K.pneumonia,E.coli,P.aeruginosa,A.baumannii and S.aureus.The detected bacteria have high resistance to antibacterial agents.Doctor should pay attention to timely and repeated detection in these patients and take the preventive measures according to the results of bacteria culture and drug sensitive tests.