Evaluation of clinical findings on 10 063 prognance women for second-trimester antenatal screening in Lanzhou

Objective: To investigate the clinic value of screening chromosomal diseases and abnormal pregnancy by maternal serum examination during second trimester of pregnancy.Methods: Auto-DELFLA are used to test the concentrations of AFP and free β-HCG in the serum of mid-pregnant women,then the results were analyzed with 2T Risk calculator and managing software to determine the fetal risk of DS and NTD,considering weight,maternal age,gestational week,etc.Results: of the 10,063 pregnant women undergoing antenatal screening,327(3.25%) were considered as high risk of DS,45(0.45%)cases suggest trisomy-18,277(2.75%) cases are NTD.315 of the high-risk cases underwent amino fluid examination,of which 9 were diagnosed DS,3 were trisomy-18 and 4 were other chromosome abnormities.By B ultrasonic,69 were diagnosed NTD.Conclusions: This study suggests that complementary measures,such as routine antenatal US,maternal serum screening and antenatal diagnosis,have important values in predicting fetal chromosomal diseases and help reduce the birth defect rate.