2001•Zhonghua miniao waike zazhiRequires access
Expression of Fas and FasL in renal cell carcinoma
Yili Liu
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Abstract
Objective To detect and evaluate the expression of Fas and FasL in renal cell carcinomas. Methods Fas and FasL expressions were assayed by means of immunohistochemical SP technique in 46 cases of renal cell carcinomas and in 15 cases of controlled normal kidney tissues. Results Fas expression rate in renal cell carcinomas was lower than in the expression in the controlled normal kidney tissues ( P 0.05),but FasL expression rate in renal cell carcinoma was higher than in controlled normal kidney tissues( P 0.05).The expression of Fas and FasL had a correlation in normal kidney tissues ( r =0.689, P 0.05), but not in renal cell carcinomas( r =0.143). The expression of FasL between lymph node involved group and lymph node uninvolved group, more than 5 year survival group and less than 5 year group was significantly different. Conclusions Dysfunction of the interaction between Fas and FasL might contribute to malignant transformation of renal cell carcinomas. FasL had some relation with tumor metastasis.Fas and FasL expressions might serve as a prognostic factor of renal cell carcinomas.