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The expression and clinical significance of Fas and FasL in human breast carcinoma

Yu Li

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Abstract

Objective:To study the expression of Fas and FasL in human breast carcinoma,explore the relationship between the expression levels and lymphatic metastasis.Methods:Immunohistochemistry LSAB method was used to detect the expression of Fas and FasL in 50 breast carcinoma tissues and 12 normal breast tissues.Results:The expression of Fas and FasL had significant difference between breast carcinoma tissues and normal breast tissues(P0.05).The positive expression rates of Fas and FasL were 38% and 82%,respectively.The positive expression rate of FasL in breast carcinoma was significantly higher than that in normal tissues(P0.05),while the positive expression rate of Fas was significantly lower than that in normal tissues(P0.05).Lymphatic metastasis was effected by the expression of Fas(P0.05).Conclusion:The abnormal expression of Fas and FasL are related to clinical features and prognosis of human breast carcinoma.

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What this paper is about

Objective:To study the expression of Fas and FasL in human breast carcinoma,explore the relationship between the expression levels and lymphatic metastasis.Methods:Immunohistochemistry LSAB method was used to detect the expression of Fas and FasL in 50 breast carcinoma tissues and 12 normal breast tissues.Results:The expression of Fas and FasL had significant difference between breast carcinoma tissues and normal breast tissues(P0.05).The positive expression rates of Fas and FasL were 38% and 82%,respectively.The positive expression rate of FasL in breast carcinoma was significantly higher than that in normal tissues(P0.05),while the positive expression rate of Fas was significantly lower than that in normal tissues(P0.05).Lymphatic metastasis was effected by the expression of Fas(P0.05).Conclusion:The abnormal expression of Fas and FasL are related to clinical features and prognosis of human breast carcinoma.

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Available abstract

Objective:To study the expression of Fas and FasL in human breast carcinoma,explore the relationship between the expression levels and lymphatic metastasis.Methods:Immunohistochemistry LSAB method was used to detect the expression of Fas and FasL in 50 breast carcinoma tissues and 12 normal breast tissues.Results:The expression of Fas and FasL had significant difference between breast carcinoma tissues and normal breast tissues(P0.05).The positive expression rates of Fas and FasL were 38% and 82%,respectively.The positive expression rate of FasL in breast carcinoma was significantly higher than that in normal tissues(P0.05),while the positive expression rate of Fas was significantly lower than that in normal tissues(P0.05).Lymphatic metastasis was effected by the expression of Fas(P0.05).Conclusion:The abnormal expression of Fas and FasL are related to clinical features and prognosis of human breast carcinoma.

Key concepts: Fas ligand, Breast carcinoma, Medicine, Immunohistochemistry, Apoptosis, Lymphatic system, Carcinoma, Metastasis

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