Clinical study on the varied dosages of DUHUO JISHENG DECOCTION combined with exercise therapy in the treatment of knee osteoarthritis

Objective:To observe the clinical curative effects of the varied dosages of DUHUO JISHENG DECOCTION combined with exercise therapy in the treatment of knee osteoarthritis.Methods:One hundred and twenty-eight patients met the criteria were randomly divided into 2 groups,64 cases in each group.Patients in the treatment group were administrated with the varied dosages of DUHUO JISHENG DECOCTION combined with exercise therapy,while the others in the control group were administrated with varied dosages of DUHUO JISHENG DECOCTION only.According to the knee comprehensive score sheet which was formulated by Lin Zhixiong,the curative effects of the patients were evaluated from the following 6 aspects as joint rest pain,joint motion pain,joint swelling,joint tenderness,joint range of motion and walking conditions 1 month and 12 months after the treatment respectively.Results:One month after the treatment,there was no statistical difference in the curative effects between the two groups(Z=-0.498,P=0.618),while 12 months after the treatment,the curative effects of treatment group were better than those of control group(Z=-2.648,P=0.008).Conclusion:The method of varied dosages of DUHUO JISHENG DECOCTION combined with exercise therapy has a long-lasting and stable curative effect in the treatment of knee osteoarthritis,it is worth popularizing in clinic.