Effect of sodium ferulate on proteinuria and renal function in patients with diabetic nephropathy

Objective To study the effects of sodium ferulate on proteinuria and renal function in patients with diabetic nephropathy.Methods 84 patients with diabetic nephropathy were divided into two groups at random.According to the level of proteinuria and renal function,the patients of each group were divided into 2 subgroups(clinical stage with normal and abnormal renal function).The controls were treated with Chinese medicine to eliminate the toxicant and control blood pressure and blood sugar levels.The patients in the study group were treated with intravenous infusion of sodium ferulate every day for 4 weeks.Other treatment was the same to the controls.Results After treatment,the serum creatinine and urea nitrogen in the clinical normal renal function subset of the study group were significantly reduced compared with those of before(P0.05),especially the quantity of urine protein during 24 hours(P0.01).While those indices in renal inadequacy subset in the study group also decreased,but no significance were found before and after the treatment between the subsets(P0.05).However,when compared with each controls,those indexes in the clinic normal renal function had no significance before treatment(P0.05).While after treatment the quantity of urine protein during 24 hours,the serum creatinine and urea nitrogen in the renal inadequacy subset of the study group were significantly reduced(P0.05).Conclusion Sodium ferulate may decrease urine protein and improve the renal function during distinct stages of diabetic nephropathy.