Effect of High Frequency Oscillatory Ventilation Combined with Pulmonary Surfactant on Severe Meconium Aspiration Syndrome

Objective To investigate the effect of high frequency oscillatory ventilation combined with tracheal instillation of pulmonary surfactant(Curosurf) on severe meconium aspiration syndrome(MAS). Methods Thirty cases of severe MAS were randomly divided into two groups, with 15 cases in each group. The control group was given normal frequency ventilation combined with endotracheal instillation of pulmonary surfactant. The observation group was given high frequency oscillatory ventilation combined with endotracheal instillation of pulmonary surfactant. Curative efficacy,PaO2,PaO2/ inspired oxygen concentration(FiO2),oxygenation index(OI),duration of mechanical ventilation and length of hospital stay were compared between the two groups. Results Compared with control group, the duration of mechanical ventilation and length of hospital stay significantly decreased in observation group(P0.05). With the increase in treatment time,PaO2,PaO2 /FiO2 and OI in observation group were significantly better than those in control group(P 0.05). Conclusion High frequency oscillatory ventilation combined with early application of pulmonary surfactant reduces inflammatory response and contributes to the treatment of severe MAS in children.