Elimination of florfenicol residue in Paralichthys olivaceus(T&S)

The elimination of florfenicol in Paralichthys olivaceus(TS) was studied by oral administration.The concentrations of florfenicol in P.olivaceus(TS) were determined by HPLC.The results showed that:1)After oral administration at a dose of 50mg/kg for five consecutive days,the concentration of florfenicol in the tissues are ranked as:bloodvisceral massmuscle.The drug concentration in tissues stabilized after 6d,but florfenicol concentration in liver and kidney at 10d and 14d showed rebound phenomenon.2)T1/2 were 32.09～40.73h,which showed the faster elimination and the less residual amount of florfenicol in the body.However,residual concentrations in the kidney and liver were more obvious.3) To explore the development of off-drug period,considering edible parts and MRL standard(0.1 μg /g),under the culture conditions of P.olivaceus:average temperature of 16~18℃,off-drug period ≥18d,the product of temperature and time is no less than 324 degree·days.