2014•Zhongguo yaolixue tongbaoRequires access

Effect of G protein-coupled estrogen receptor on the occurrence and development of estrogen related cancer

Zhao Pi-we

Abstract

Estrogen or estrogenic substances can act via not only typical estrogen receptor α and β but also G protein-coupled estrogen receptor( GPER). GPER is a crucial factor which can play an essential part in the non-genomic transduction pathway through which estrogen realizes its cellular functions,especially in the occurrence and treatment of estrogen related cancer. Here is a brief review concerning the current advancements on the role of GPER in estrogen related cancer.

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Key concepts: GPER, Estrogen receptor, Estrogen, Estrogen receptor beta, Estrogen receptor alpha, Estrogen-related receptor gamma, Cancer, Breast cancer