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RP-HPLC Determination of the Content and the Related Substances of Telmisartan

Zheng Guo-gang

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Abstract

Objective:To determine the content and the related substances of telmisartan by RP-HPLC. Methods:The separation was performed on an Alltech Alltima C_(18) column(150mm×4.6mm,5μm) ,the mobile phase was composed of acetonitrile-0.01 mol·L~(-1) ammonnium acetate (60:40, to make up the pH 6.0 with acetic acid) , the flow rate was 1.0 mL·min~(-1),the detection was carried out with a dinode array detector at 298 nm and 255 nm respectively. Results:The linear range of the determination by RP-HPLC was 50- 250μg·mL~(-1), the correlation coefficient was 0.9999,the least detective range was 0.04 ng,the precision in a day(RSD0.5% )and during the day(RSD0.5%)were good. Conclusions:The method is simple,rapid and the results is accurate.

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What this paper is about

Objective:To determine the content and the related substances of telmisartan by RP-HPLC. Methods:The separation was performed on an Alltech Alltima C_(18) column(150mm×4.6mm,5μm) ,the mobile phase was composed of acetonitrile-0.01 mol·L~(-1) ammonnium acetate (60:40, to make up the pH 6.0 with acetic acid) , the flow rate was 1.0 mL·min~(-1),the detection was carried out with a dinode array detector at 298 nm and 255 nm respectively. Results:The linear range of the determination by RP-HPLC was 50- 250μg·mL~(-1), the correlation coefficient was 0.9999,the least detective range was 0.04 ng,the precision in a day(RSD0.5% )and during the day(RSD0.5%)were good. Conclusions:The method is simple,rapid and the results is accurate.

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Available abstract

Objective:To determine the content and the related substances of telmisartan by RP-HPLC. Methods:The separation was performed on an Alltech Alltima C_(18) column(150mm×4.6mm,5μm) ,the mobile phase was composed of acetonitrile-0.01 mol·L~(-1) ammonnium acetate (60:40, to make up the pH 6.0 with acetic acid) , the flow rate was 1.0 mL·min~(-1),the detection was carried out with a dinode array detector at 298 nm and 255 nm respectively. Results:The linear range of the determination by RP-HPLC was 50- 250μg·mL~(-1), the correlation coefficient was 0.9999,the least detective range was 0.04 ng,the precision in a day(RSD0.5% )and during the day(RSD0.5%)were good. Conclusions:The method is simple,rapid and the results is accurate.

Key concepts: Chemistry, Chromatography, Telmisartan, High-performance liquid chromatography, Acetic acid, Correlation coefficient, Linear range, Content determination

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