Ischemic Post-conditioning Attenuates Myocardial Ischemia Reperfusion Injury Through Inhibiting Oxidative Stress in Rabbits

Objective:To investigate the impact of ischemic preconditioning and ischemic postconditioning on cardiac function,malondialdehyde(MDA) and superoxide dismutase(SOD) during heart ischemia/reperfusion injury in rabbits.Methods:Eighteen rabbits were randomly divided into 3 groups(n= 6 each): control group,ischemic preconditioning group and ischemic postconditioning group.Left ventricular systolic pressure(LVSP),±dp/dtmax of the heart during reperfusion were determined.Ptasma MDA content and SOD activity were also measured.Results:Compared with those of control,LVSP and ±dp/dtmax of the heart were better recovered during reperfusion in both of the conditioned groups(P0.01).The MDA concentrations in plasma in both of the conditioned groups were significantly lower than those in the control group(P0.05) and the SOD activities in plasma were significantly higher than those in the control group(P0.05).Conclusion:The results demonstrate that ischemic post-conditioning,like ischemic preconditioning,improve cardiofunction,depresses the production of oxygen free radicals and attenuate reperfusion injury in ischemic heart.