Protective Effect of Baicalin on Acute Lung Injury Rats Induced with Lipopolysaccharide

Objective:To investigate the protective effect of baicalin on acute lung injury(ALI) rats induced with lipopolysaccharide(LPS).Method:SD rats were randomly divided into 6 groups(n=10): control,ALI model,dexamethasone(5 mg · kg-1) and baicalin groups(50,100,200 mg · kg-1).After 1 h of the last administration,the model of ALI was established by intratracheal instillation of LPS.After 6 h of the LPS instillation,the serum was collected for determinating the interleukin(IL)-1β,IL-8 and tumor necrosis factor(TNF)-α levels.In addition,the ratios of lung wet to dry weight and water content were also measured.The activity of myeloperoxidase(MPO) and cyclooxygenase(COX)-2 in lung was determinated.Result:Compared with control group,ALI group exhibited a higher wet to dry radio and water content in lung(P0.05).Compared with ALI model group,baicalin significantly decreased the levels of IL-1β,IL-8 and TNF-α in serum(P0.05),reduced the wet to dry ratio and water content in a dose-dependent manner(P0.05).Moreover,baicalin significantly decreased the activity of MPO and COX-2 in lung(P0.05).Conclusion:Baicalin had a protective effect on ALI rats induced with LPS and the mechanism maybe related to the suppression of inflammation.