2015•Laboratory Medicine and ClinicRequires access
Diagnosis value of apoptosis inhibition protein Livin and Survivin in gastric cancer
Yang Shao-ron
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Abstract
Objective To explore the diagnosis value of apoptosis inhibition protein Livin and Survivin in gastric cancer.Methods Totally 170 cases of operation or endoscopic biopsy specimens in our hospital were selected as the object,including 45 cases of gastric cancer tissues,37 cases of atrophic gastritis,29 cases of superficial gastritis,33 cases of gastric mucosa dysplasia,26 cases of normal gastric tissue.Compared the expression positive rate of Livin,Survivin of each group,and analysised the relationship between the Livin and Survivin in gastric cancer.Results The positive rate of Livin and Survivin of gastric carcinoma tissues was significantly higher than other groups(P0.05);wherein the atrophic gastritis,gastric mucosa dysplasia,Livin positive rate was significantly higher than that of normal tissue,atrophic gastritis,superficial gastritis with dysplasia of gastric mucosa,positive rate of Survivin was significantly higher than that in normal tissue(P0.05).The positive expression of Livin related with tissue differentiation,TNM stage(P0.05);the positive expression of Survivin related with the degree of tissue infiltration,TNM stage(P0.05).The positive rate of Livin was 57.78%,the positive rate of Survivin was 64.44%,both were positive in 21 cases,the expression had no obvious correlation(χ2=1.076,P0.05).Conclusion Apoptosis inhibition protein Livin and Survivin expression in gastric cancer tissue increased significantly,two kinds of genetic testing can be used as one of indexes of gastric cancer screening.