2001•Journal of Huaihai MedicineRequires access

Effect of mifepristone on the expression of bcl-2,P53 and ER,PR in uterine leiomyoma

Tao Yi-shen

Abstract

Objective To study the effect of mifepristone on the expression of bcl 2?P53 and estrogen receptor(ER),progestogen receptor(PR) in uterine leiomyoma.Methods The expression of bcl 2,P53 protein,and ER,PR was determined immunohistochemically in leiomyoma of 12 mifepristone treated(experimental group) cases,which were compared with 12 untreated patients(control group).Results The positive rate of bcl 2 and ER,PR in experimental group was significantly lower than that in control group( P 0.01).No signficant difficance of the positive rate of P53 was observed between the two groups ( P 0.05).Conclusion Mifepristone can significantly decrease the expression of bcl 2,and ER,PR in leiomyoma which can induce leiomyoma cell apoptosis.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Mifepristone, Medicine, Leiomyoma, Progestogen, Uterine leiomyoma, Estrogen receptor, Progesterone receptor, Apoptosis