Intervention on serum hs-CRP and TNF-α of patients with acute coronary syndrome by Clopidogrel Sulfate

Objective To explore Clopidogrel Sulfate's effect of anti-platelet and anti-inflammatory in patients with acute coronary syndrome(ACS).Methods 86 patients with ACS were divided into observation group and control group, with 43 cases in each group.Basic scheme referring to ACS treatment guidelines was used in all patients,and control group was given aspirin,yet observation group was given Clopidogrel Sulfate and Aspirin,and all patients were treated for 30 d.All patients' serum hs-CRP and TNF-α were tested before treatment,7 d and 30 d after treatment.Results There was no statistical difference on ACS patients serum hs-CRP and TNF-α before treatment(P 0.05).The serum hs-CRP and TNF-α in observation group both decreased 7 d and 30 d after treatment(P 0.05 or P 0.01),and serum hs-CRP and TNF-α in control group decreased 30 d after treatment(P 0.05),yet serum hs-CRP and TNF-α in observation group were both lower than those of control group in corresponding time of 7 d and 30 d after treatment(P 0.05).Conclusion Clopidogrel Sulfate decreases ACS patients' serum hs-CRP and TNF-α levels,and it has good anti-platelet and anti-inflammatory effect.