Clinical Observation of Jiangu Capsule Combined with Conventional Scheme in the Treatment of Ankylosing Spondylitis Complicating with Bone Rarefaction

OBJECTIVE:To observe therapeutic efficacy and safety of Jiangu capsule combined with conventional scheme in the treatment for ankylosing spondylitis complicating with bone rarefaction. METHODS:90 ankylosing spondylitis patients with bone rarefaction were randomly divided into control group,observation group 1 and observation group 2. Control group was given Sulfasalazine tablet 1.0 g orally bid and Celecoxib capsules 0.2 g orally bid. On the basis of control group,observation group 1 was additionally given allen sodium phosphate 70 mg once a week;observation 2 group was given Jiangu capsule 1.75 g orally tid. A treatment course of 3 groups lasted for 4 weeks;and they received 6 courses of treatment. The clinical efficacy,and TCM symptoms score and physical sign,lab indicators,disease activity index,bone metabolic biochemical index,bone density and calcaneus strength index and the incidence of ADR before and after treatment were observed in 3 groups. RESULTS:Total effective rate of 3 groups was in descending order,such as observation group 2observation group 1control group;there was statistical significance among 3 groups(P0.05);In three groups,the TCM symptoms score,occiput to wall distance,finger to floor distance, mandible to sternum distance,lab indicators,disease activity index,BGP,PICP,DPD and ICTP after treatment were significantly lower than before;and those of observation group 1 and 2 were lower than those of control group;thoracic activity,lordosis restricted,spinal mobility,PTH,Serum BALP,bone density value and calcaneus strength index after treatment were obviously higher than before;those of observation group 1 and 2 were higher than those of control group;there was statistical significance(P 0.05);but there was no statistical significance between 2 observation groups(P0.05). The incidence of ADR had no statistical significance among 3 groups(P0.05). CONCLUSIONS:Jiangu capsule is effective and safe in combination treatment for osteoporosis complicating with ankylosing spondylitis.