Clinical Significance of Combined Assay of Five Serum Tumor Markers in Diagnosis and Follow-up of Gastric Cancer and Colorectal Carcinoma

Objective To evaluate the measurement of the serum levels of CA199,CEA,CA242,CA125 and CA153 in gastric cancer and colorectal carcinoma diagnosis and follow-up.Methods The serum levels of the 5 kinds of serum tumor markers,were measured using electroche miluminescene analyzer in 165 patients with gastric cancer and colorectal carcinoma,82 patients with benign digestive disease and 160 healthy examinations.Results The levels of the 5 kinds of serum tumor markers were significantly higher in gastric cancer and colorectal Carcinoma than that of two other controls(P0.01).The levels of serum tumor markers declined significantly after radical operation.The rate of recurrence or metastasis was 71.05% in that the levels of serum tumor markers were not decreased to normal after radical operation.The rate of recurrence or metastasis was 76% in patients that the levels of serum tumor markers were reelevated after radical operation.Conclusion The various serum tumor markers mentioned above have certain value in the diagnosis and the following up for the gastric cancer and colorectal carcinoma and can be used to monitor tumor recurrence and metastasis.The simultaneously combined assay raised sensitivity and negative predictive rate;the serial combined assay can raise specificity and positive predictive rate.