PLATELET ACTIVATION IN PATIENTS WITH UNSTABLE ANGINA PECTORIS

Objective:To assess the platelet activation state in patients with unstable angina pectoris(UAP) and to investigate the relationship between the severity of coronary artery stenosis and platelet activation. Methods:CD63,CD62P and thrombospondin were detected using flow cytometry in 55 patients with UAP,32 with stable angina pectoris(SAP)(both given aspirin 75 mg/d) and 40 healthy controls.42 patients with UAP underwent elective coronary arteriography.There were 10 patients with single vessel disease,21 with double vessel disease and 11 with three vessel disease.Results:The three parameters in UAP group were significantly higher than in SAP and controls.There was no significant difference between male and female.Groups of double and three vessel disease had significantly increased CD63 and thrombospondin expression comparing with single vessel disease.Conclusion:There is elevated platelet activation in patients with UAP.Platelet activation raises with the increase of severity of coronary artery disease.Low dose oral aspirin(75mg/d) can not completely inhibit platelet activation in patients with UAP.